Ketamine-propofol for Peds Fracture Reduction

13 Jul

Advantages of combination

  • increased anesthetic synergy leading to decreased doses,
  • decreased dysphoric emergence from ketamine
  • decreased pain of propofol injection

Pilot study of 20 children with forearm fractures needing closed reduction with procedural sedation

  • showed rapid recovery (average 38 min from time of ketamine injection to suitability for discharge)
  • no clinically significant complications when using 0.5 mg/kg of ketamine followed by 1 mg/kg of propofol


  • one small study, but one of many out there
  • ketamine-propofol combo worth considering, need less of either to get a desired effect

Submitted by F. DiFranco.

Reference(s): Sharieff, GQ, et al. Ketamine-propofol combination sedation for fracture reduction in the pediatric emergency department. Pediatric Emergency Care. 23(12):881-884, Dec 2007.; picture


Leave a Reply

Fill in your details below or click an icon to log in: Logo

You are commenting using your account. Log Out /  Change )

Google+ photo

You are commenting using your Google+ account. Log Out /  Change )

Twitter picture

You are commenting using your Twitter account. Log Out /  Change )

Facebook photo

You are commenting using your Facebook account. Log Out /  Change )


Connecting to %s

%d bloggers like this: