Loperamide for acute diarrhea in children

18 Jul

QUICK HITS:

Loperamide has been generally discouraged for acute diarrhea in children

•However, there is evidence that its use is safe and effective in children with acute diarrhea

•One study found that it is well tolerated and significantly shortens duration of diarrhea and severity of symptoms in children from age 2-11

•A systematic review concluded that loperamide may be a useful adjunct for acute diarrhea in children > 3 yo with minimal dehydration

Do NOT use loperamide for infants, malnourished, very dehydrated, systemically ill or if they have bloody diarrhea as adverse events outweigh benefits00

Submitted by F. DiFranco.

Reference(s): Kaplan MA, et al. A multicenter randomized controlled trial of a liquid loperamide product versus placebo in the treatment of acute diarrhea in children. Clinical Pediatrics. 38(10):579-591, October 1999.; Li ST, Grossman DC, Cummings P. Loperamide therapy for acute diarrhea in children: systematic review and meta-analysis. PLoS Med. 4(3):e98, March 2007.; picture

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