ITP (quick hits)

20 Jun

2 requirements:

  • isolated thrombocytopenia
  • absence of another cause.

 

pathogenesis of immune thrombocytopenia (ITP)

  • increased platelet destruction
  • inhibition of megakaryocyte platelet production via IgG autoantibodies, often directed against platelet membrane glycoproteins such as GPIIb/IIIa.

 

Symptoms:

  • range from bleeding diatheses to petechiae.
  • Gingival bleeding,
  • GI bleeding,
  • epistaxis

 

Order CBC along with smear to assess for other causes. HIV and HCV testing is recommended as well.

 

For severe thrombocytopenia and/or bleeding, emergent hem consultation is warranted.

For less severe sx, non urgent f/u.

 

Submitted by J. Rothstein.

 

References: uptodate.com; picture

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