ITP (quick hits)

20 Jun

2 requirements:

  • isolated thrombocytopenia
  • absence of another cause.


pathogenesis of immune thrombocytopenia (ITP)

  • increased platelet destruction
  • inhibition of megakaryocyte platelet production via IgG autoantibodies, often directed against platelet membrane glycoproteins such as GPIIb/IIIa.



  • range from bleeding diatheses to petechiae.
  • Gingival bleeding,
  • GI bleeding,
  • epistaxis


Order CBC along with smear to assess for other causes. HIV and HCV testing is recommended as well.


For severe thrombocytopenia and/or bleeding, emergent hem consultation is warranted.

For less severe sx, non urgent f/u.


Submitted by J. Rothstein.


References:; picture


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